TFEB

TFEB
Identifiers
Aliases	TFEB, ALPHABHLHE35, TCFEB, transcription factor EB
External IDs	OMIM: 600744; MGI: 103270; HomoloGene: 5182; GeneCards: TFEB; OMA:TFEB - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	41,736,259 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	48,103,344 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; apex of heart; ; granulocyte; ; blood; ; C1 segment; ; inferior olivary nucleus; ; spleen; ; inferior ganglion of vagus nerve; ; monocyte;
	Top expressed in
	muscle of thigh; ; granulocyte; ; esophagus; ; triceps brachii muscle; ; temporal muscle; ; vastus lateralis muscle; ; ankle; ; iris; ; ciliary body; ; gastrocnemius muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein dimerization activity; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus;
Biological process	autophagy; positive regulation of transcription, DNA-templated; embryonic placenta development; lysosome organization; adaptive immune response; transcription, DNA-templated; positive regulation of autophagy; positive regulation of transcription by RNA polymerase II; immune system process; humoral immune response; regulation of transcription, DNA-templated; lysosome localization;
	Sources:Amigo / QuickGO
Orthologs
	7942
	21425
	ENSG00000112561
	ENSMUSG00000023990
	P19484
	Q9R210
	NM_001167827; NM_001271943; NM_001271944; NM_001271945; NM_007162
	NM_001161722; NM_001161723; NM_011549
	NP_001161299; NP_001258872; NP_001258873; NP_001258874; NP_009093
	NP_001155194; NP_001155195; NP_035679
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor EB is a protein that in humans is encoded by the TFEB gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112561 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023990 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Carr CS, Sharp PA (Aug 1990). "A helix-loop-helix protein related to the immunoglobulin E box-binding proteins". Molecular and Cellular Biology. 10 (8): 4384–8. doi:10.1128/mcb.10.8.4384. PMC 360994. PMID 2115126.
^ "Entrez Gene: TFEB transcription factor EB".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112561 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023990 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2115126-5] Carr CS, Sharp PA (Aug 1990). "A helix-loop-helix protein related to the immunoglobulin E box-binding proteins". Molecular and Cellular Biology. 10 (8): 4384–8. doi:10.1128/mcb.10.8.4384. PMC 360994. PMID 2115126.

[entrez-6] "Entrez Gene: TFEB transcription factor EB".

[1]

[2]

[3]

[4]

[5]

[6]