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This article addresses the history of transgender people across the British Isles in the United Kingdom, the British colonies and the Kingdom of England until the present day. Transgender people were historically recognised in the UK by varying titles and cultural gender indicators, such as dress. People dressing and living differently from their sex assignment at birth and contributing to various aspects of British history and culture have been documented from the 14th century to the present day. In the 20th century, advances in medicine, social and biological sciences and transgender activism have influenced transgender life in the UK.