U.S. Route 378

U.S. Route 378
U.S. Route 378
	US 378 highlighted in red
Route information
	Auxiliary route of US 78
Length	234.30 mi (377.07 km)
Existed	September 1951–present
Major junctions
West end	US 78 / SR 10 / SR 17 / SR 47 in Washington, GA
	US 178 in Saluda, SC; US 1 twice in South Carolina; I-20 near West Columbia, SC; I-26 in West Columbia, SC; US 21 / US 176 / US 321 in Columbia, SC; US 76 in Columbia, SC; I-77 in Columbia, SC; US 15 / US 401 / US 521 in Sumter, SC; I-95 near Turbeville, SC; US 52 near Lake City, SC;
East end	; US 501 Bus. in Conway, SC
Location
Country	United States
States	Georgia, South Carolina
Counties	GA: Wilkes, Lincoln; SC: McCormick, Edgefield, Saluda, Lexington, Richland, Sumter, Clarendon, Florence, Marion, Horry
Highway system
	United States Numbered Highway System; List; Special; Divided;

U.S. Route 378 (US 378) is a spur of US 78 in the U.S. states of Georgia and South Carolina. The U.S. Highway runs 234.30 miles (377.07 km) from US 78, Georgia State Route 10 (SR 10), SR 17, and SR 47 in Washington, Georgia, east to US 501 Business in Conway, South Carolina. US 378 connects the Central Savannah River Area in both states with the Midlands and Pee Dee regions of South Carolina. The U.S. Highway's western portion, which connects Washington and Lincolnton in Georgia and McCormick, Saluda, and Lexington in South Carolina, is mainly a rural highway. US 378 is a major suburban and urban highway through Lexington and South Carolina's state capital, Columbia. The highway has a lengthy concurrency with US 76 between Columbia and Sumter and serves as a major route between the Midlands and the Myrtle Beach area, between which the highway has a business route through Lake City.

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^ "Highway Route Number Changes in State Listed". The Index-Journal. Greenwood, South Carolina. February 9, 1952. p. 7. Retrieved August 14, 2019 – via Newspapers.com.