Back سرطان الرحم Arabic ইউটেৰাইন কেন্সাৰ Assamese জরাযুর ক্যান্সার Bengali/Bangla Càncer d'úter Catalan Uteruskarzinom German ރަހިމުގެ ކެންސަރު DV Cáncer uterino Spanish Umetokiko minbizi Basque سرطان رحم Persian Tumeur de l'utérus French

Uterine cancer

Uterine cancer
Other namesWomb cancer
Diagram of uterus with labeled origins of cancer types.
SpecialtyGynecology, oncology
SymptomsEndometrial cancer: vaginal bleeding, pelvic pain[1]
Uterine sarcoma: vaginal bleeding, mass in the vagina[2]
TypesEndometrial cancer, uterine sarcoma[3]
Risk factorsEndometrial cancer: obesity, metabolic syndrome, type 2 diabetes, tamoxifen use, unopposed estrogens, late menopause, family history of the condition[1]
Uterine sarcoma: radiation therapy to the pelvis[2]
TreatmentSurgery, radiation therapy, chemotherapy, hormone therapy, targeted therapy[1][2]
Frequency3.8 million (2015)[4]
Deaths90,000 (2015)[5]

Uterine cancer, also known as womb cancer, includes two types of cancer that develop from the tissues of the uterus.[3] Endometrial cancer forms from the lining of the uterus, and uterine sarcoma forms from the muscles or support tissue of the uterus.[1][2] Endometrial cancer accounts for approximately 90% of all uterine cancers in the United States.[6] Symptoms of endometrial cancer include changes in vaginal bleeding or pain in the pelvis.[1] Symptoms of uterine sarcoma include unusual vaginal bleeding or a mass in the vagina.[2]

Risk factors for endometrial cancer include obesity, metabolic syndrome, type 2 diabetes, taking pills that contain estrogen without progesterone, a history of tamoxifen use, late menopause, and a family history of the condition.[7][1] Risk factors for uterine sarcoma include prior radiation therapy to the pelvis.[2] Diagnosis of endometrial cancer is typically based on an endometrial biopsy.[1] A diagnosis of uterine sarcoma may be suspected based on symptoms, a pelvic exam, and medical imaging.[2]

Endometrial cancer can often be cured while uterine sarcoma typically is harder to treat.[3] Treatment may include a combination of surgery, radiation therapy, chemotherapy, hormone therapy, and targeted therapy.[1][2] Just over 80% of women survive more than 5 years following diagnosis.[8]

In 2015 about 3.8 million women were affected globally and it resulted in 90,000 deaths.[4][5] Endometrial cancer is relatively common while uterine sarcomas are rare.[3] In the United States, uterine cancers represent 3.5% of new cancer cases.[8] They most commonly occur in women between the ages of 45 and 74 with a median age of diagnosis of 63.[8]

  1. ^ a b c d e f g h "Endometrial Cancer Treatment". National Cancer Institute. 26 April 2018. Retrieved 3 February 2019.
  2. ^ a b c d e f g h "Uterine Sarcoma Treatment". National Cancer Institute. 3 October 2018. Retrieved 3 February 2019.
  3. ^ a b c d "Uterine Cancer". National Cancer Institute. 1 January 1980. Retrieved 3 February 2019.
  4. ^ a b "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1545–1602. October 2016. doi:10.1016/S0140-6736(16)31678-6. PMC 5055577. PMID 27733282.
  5. ^ a b "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1459–1544. October 2016. doi:10.1016/S0140-6736(16)31012-1. PMC 5388903. PMID 27733281.
  6. ^ Felix AS, Brinton LA (September 2018). "Cancer Progress and Priorities: Uterine Cancer". Cancer Epidemiology, Biomarkers & Prevention. 27 (9): 985–994. doi:10.1158/1055-9965.EPI-18-0264. PMC 6504985. PMID 30181320.
  7. ^ "Endometrial Cancer Risk Factors". www.cancer.org. Retrieved 2021-09-13.
  8. ^ a b c "Uterine Cancer - Cancer Stat Facts". SEER. Retrieved 3 February 2019.

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