Akuaporin 1

AQP1
Struktur yang tersedia
PDB	Pencarian Ortolog: PDBe RCSB
Daftar kode id PDB
	4CSK, 1FQY, 1H6I, 1IH5
Pengidentifikasi
Alias	AQP1, AQP-CHIP, CHIP28, CO, aquaporin 1 (Colton blood group)
ID eksternal	OMIM: 107776 MGI: 103201 HomoloGene: 68051 GeneCards: AQP1
Lokasi gen (Tikus)
Kr.	Kromosom 6 (tikus)
Akhir	55,325,540 bp
Pola ekspresi RNA
	; ;
	Referensi data ekspresi selengkapnya
Ontologi gen
Fungsi molekuler	• aktivitas transporter; • GO:0051739, GO:0015251 aktivitas transporter transmembran amonium; • aktivitas transporter transmembran nitrogen monoksida; • aktivitas saluran kation teraktivasi cGMP intraseluler; • aktivitas saluran kalium; • GO:0022891 aktivitas transporter transmembran; • aktivitas transporter transmembran karbon dioksida; • GO:0001948, GO:0016582 Ikatan protein plasma; • aktivitas transporter transmembran air; • GO:0015388 aktivitas transporter transmembran ion kalium; • aktivitas transporter transmembran gliserol; • aktivitas saluran air; • pengikatan reseptor efrin; • pengikatan protein identik; • aktivitas saluran;
Komponen seluler	• sitoplasma; • membran inti; • symbiont-containing vacuole membrane; • membran; • Inti sel; • membran plasma apikal; • komponen integral membran; • Membran sel; • apical part of cell; • basal plasma membrane; • integral component of plasma membrane; • brush border membrane; • membran plasma basolateral; • Sarkolema; • brush border; • symbiont-containing vacuole; • Akson; • neuron projection; • axon terminus; • extracellular exosome;
Proses biologis	• cellular response to retinoic acid; • cellular response to mechanical stimulus; • cellular response to copper ion; • cellular response to nitric oxide; • respons seluler terhadap hipoksia; • cellular response to cAMP; • carbon dioxide transmembrane transport; • positive regulation of fibroblast proliferation; • cellular homeostasis; • pancreatic juice secretion; • cGMP biosynthetic process; • cellular response to stress; • cellular response to salt stress; • cellular response to inorganic substance; • cell volume homeostasis; • cellular response to UV; • establishment or maintenance of actin cytoskeleton polarity; • negative regulation of apoptotic process; • cellular response to dexamethasone stimulus; • positive regulation of angiogenesis; • odontogenesis; • renal water transport; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • cellular response to mercury ion; • nitric oxide transport; • cellular hyperosmotic response; • bicarbonate transport; • positive regulation of saliva secretion; • renal water homeostasis; • multicellular organismal water homeostasis; • transepithelial water transport; • carbon dioxide transport; • cellular response to hydrogen peroxide; • cerebrospinal fluid secretion; • potassium ion transmembrane transport; • ammonium transmembrane transport; • cation transmembrane transport; • glomerular filtration; • potassium ion transport; • transpor air; • hyperosmotic response; • response to hormone; • positive regulation of lamellipodium assembly; • positive regulation of epithelial cell migration; • glycerol transport; • Nosisepsi; • lateral ventricle development; • water homeostasis; • positive regulation of cell migration; • secretion by cell; • secretory granule organization; • wound healing; • hyperosmotic salinity response; • response to estrogen; • lipid digestion; • camera-type eye morphogenesis; • corticotropin secretion; • renal water absorption; • metanephric descending thin limb development; • metanephric proximal straight tubule development; • metanephric proximal convoluted tubule segment 2 development; • metanephric glomerulus vasculature development; • GO:0015915 transpor; • cGMP-mediated signaling; • ion transmembrane transport; • transpor transmembran;
	Sumber:Amigo / QuickGO
Ortolog
	358
	11826
	ENSG00000240583
	ENSMUSG00000004655
	P29972; Q6JSD8; Q6JSD7
	Q02013
NM_198098; NM_000385; NM_001185060; NM_001185061; NM_001185062;
	NM_001329872
	NM_007472
	NP_001316801; NP_932766
	NP_031498
	Wikidata
Lihat/Sunting Manusia	Lihat/Sunting Tikus

Akuaporin 1 adalah protein pada manusia yang dikodekan oleh gen AQP1.

AQP1 secara luas mengekspresikan saluran air yang fungsi fisiologisnya banyak dikarakteristikkan di dalam ginjal. Protein ini ditemukan pada membran plasma basolateral dan apikal tubulus proksimal, lengan menurun lengkung Henle, dan pada bagian menurun vasa rekta. Sebagai tambahan, protein ini juga ditemukan pada sel darah merah, endotelium vaskular, saluran pencernaan, kelenjar keringat, dan paru-paru.

Akuaporin ini tidak diregulasi oleh vasopresin (ADH).

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004655 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000004655 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

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