Aromatase

CYP19A1
Struktur yang tersedia PDB Pencarian Ortolog: PDBe RCSB Daftar kode id PDB 3EQM, 3S79, 3S7S, 4GL5, 4GL7, 4KQ8
Pengidentifikasi
Alias	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM, cytochrome P450 family 19 subfamily A member 1
ID eksternal	OMIM: 107910 MGI: 88587 HomoloGene: 30955 GeneCards: CYP19A1
Lokasi gen (Tikus) Kr. Kromosom 9 (tikus)[1] Pita 9 A5.3|9 29.49 cM Awal 54,073,221 bp[1] Akhir 54,175,394 bp[1]
Pola ekspresi RNA Referensi data ekspresi selengkapnya
Ontologi gen Fungsi molekuler • iron ion binding • oxygen binding • metal ion binding • monooxygenase activity • heme binding • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • electron transfer activity • oxidoreductase activity • aromatase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • steroid hydroxylase activity Komponen seluler • endoplasmic reticulum membrane • Retikulum endoplasma • membran • komponen integral membran Proses biologis • estrogen biosynthetic process • androgen metabolic process • negative regulation of chronic inflammatory response • prostate gland growth • sterol metabolic process • negative regulation of macrophage chemotaxis • steroid biosynthetic process • female gonad development • female genitalia development • perkembangan payudara • uterus development • testosterone biosynthetic process • androgen catabolic process • positive regulation of estradiol secretion • Rantai transpor elektron Sumber:Amigo / QuickGO
Ortolog
Spesies	Manusia	Tikus
Entrez	1588	13075
Ensembl	ENSG00000137869	ENSMUSG00000032274
UniProt	P11511	P28649
RefSeq (mRNA)	NM_000103 NM_001347248 NM_001347249 NM_001347250 NM_001347251 NM_001347252 NM_001347253 NM_001347254 NM_001347255 NM_001347256 NM_031226	NM_007810 NM_001348171 NM_001348172 NM_001348173
RefSeq (protein)	NP_000094 NP_001334177 NP_001334178 NP_001334179 NP_001334180 NP_001334181 NP_001334182 NP_001334183 NP_001334184 NP_001334185 NP_112503	NP_001335100 NP_001335101 NP_001335102 NP_031836
Lokasi (UCSC)	n/a	Chr 9: 54.07 – 54.18 Mb
Pencarian PubMed	[2]	[3]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

Aromatase, juga disebutestrogen synthetase atau estrogen synthase, adalah sebuah enzim yang bertanggung jawab untuk langkah penting dalam biosintesis dari estrogen. Enzim tersebut berkode CYP19A1, sebuah anggopta dari keluarga besar sitokrome P450 (EC 1.14.14.1), yang bersifat monooksigenase yang memicu banyak reaksi yang terjadi pada steroidogenesis. Biasanya, aromatase bertanggung jawab untuk aromatisasi androgen menjadi estrogen.

1. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000032274 - Ensembl, May 2017
2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. 
3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.