Back إعادة تشكيل الفيروس Arabic Reassortment German Reagrupamiento Spanish بازآرایی Persian Recombinaison virale French 遺伝子再集合 Japanese Virale verschuiving Dutch Reasortacja genowa Polish Rearranjo Portuguese Реассортация Russian

Reassortment

The process of reassortment in biotechnology

Reassortment is the mixing of the genetic material of a species into new combinations in different individuals. Several different processes contribute to reassortment, including assortment of chromosomes, and chromosomal crossover.[1] It is particularly used when two similar viruses that are infecting the same cell exchange genetic material. In particular, reassortment occurs among influenza viruses, whose genomes consist of eight distinct segments of RNA. These segments act like mini-chromosomes, and each time a flu virus is assembled, it requires one copy of each segment.

If a single host (a human, a chicken, or other animal) is infected by two different strains of the influenza virus, then it is possible that new assembled viral particles will be created from segments whose origin is mixed, some coming from one strain and some coming from another. The new reassortant strain will share properties of both of its parental lineages.

Reassortment is responsible for some of the major genetic shifts in the history of the influenza virus. In the 1957 "Asian flu" and 1968 "Hong Kong flu" pandemics, flu strains were caused by reassortment between an avian virus and a human virus.[2][3] In addition, the H1N1 virus responsible for the 2009 swine flu pandemic has an unusual mix of swine, avian and human influenza genetic sequences.[4]

The reptarenavirus family, responsible for inclusion body disease in snakes, shows a very high degree of genetic diversity due to reassortment of genetic material from multiple strains in the same infected animal.

  1. ^ Alberts, B.; Bray, D.; Roberts, K.; Lewis, J.; Raff, M. (1997). Essential cell biology: an introduction to the molecular biology of the cell. Taylor & Francis. ISBN 978-0-8153-2045-6.
  2. ^ "1968 Pandemic (H3N2 virus)". US Centers for Disease Control and Prevention (CDC). 2019-01-22. Retrieved 2021-01-18.
  3. ^ Saunders-Hastings, Patrick R.; Krewski, Daniel (2016-12-06). "Reviewing the History of Pandemic Influenza: Understanding Patterns of Emergence and Transmission". Pathogens. 5 (4): 66. doi:10.3390/pathogens5040066. ISSN 2076-0817. PMC 5198166. PMID 27929449.
  4. ^ "Deadly new flu virus in US and Mexico may go pandemic". New Scientist. 2009-04-24. Retrieved 2009-04-26.

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