Back نازعة هيدروجين السكسينات Arabic Sukcinátdehydrogenáza Czech Succinat-Dehydrogenase German Succinato deshidrogenasa Spanish Sukzinato deshidrogenasa Basque Sukkinaattidehydrogenaasi Finnish Succinate déshydrogénase French Succinato deshidroxenase Galician Szukcinát-dehidrogenáz Hungarian Suksinat dehidrogenase ID
| succinate dehydrogenase (succinate-ubiquinone oxidoreductase) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 The structure of SQR in a phospholipid membrane. SDHA, SDHB, SDHC and SDHD | |||||||||
| Identifiers | |||||||||
| EC no. | 1.3.5.1 | ||||||||
| CAS no. | 9028-11-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| Succinate dehydrogenase | |
|---|---|
| Identifiers | |
| Symbol | Respiratory complex II |
| OPM superfamily | 3 |
| OPM protein | 1zoy |
| Membranome | 656 |
Succinate dehydrogenase (SDH) or succinate-coenzyme Q reductase (SQR) or respiratory complex II is an enzyme complex, found in many bacterial cells and in the inner mitochondrial membrane of eukaryotes. It is the only enzyme that participates in both the citric acid cycle and oxidative phosphorylation.[1] Histochemical analysis showing high succinate dehydrogenase in muscle demonstrates high mitochondrial content and high oxidative potential.[2]
In step 6 of the citric acid cycle, SQR catalyzes the oxidation of succinate to fumarate with the reduction of ubiquinone to ubiquinol. This occurs in the inner mitochondrial membrane by coupling the two reactions together.
- ^ Oyedotun KS, Lemire BD (March 2004). "The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies". The Journal of Biological Chemistry. 279 (10): 9424–9431. doi:10.1074/jbc.M311876200. PMID 14672929.
- ^ webmaster (2009-03-04). "Using Histochemistry to Determine Muscle Properties". Succinate Dehydrogenase: Identifying Oxidative Potential. University of California, San Diego. Archived from the original on 2018-10-10. Retrieved 2017-12-27.