Tronbina

Tronbina
Egitura erabilgarria PDB Ortologoaren bilaketa: PDBe RCSB PDB ID kodeen zerrenda 1A2C, 1A3B, 1A3E, 1ABI, 1ABJ, 1AD8, 1AE8, 1AI8, 1AIX, 1AWF, 1AWH, 1AY6, 1B5G, 1B7X, 1BA8, 1BB0, 1BCU, 1BHX, 1BMM, 1BMN, 1BTH, 1C1U, 1C1V, 1C1W, 1C4U, 1C4V, 1C4Y, 1C5L, 1C5N, 1C5O, 1CA8, 1D3D, 1D3P, 1D3Q, 1D3T, 1D4P, 1D6W, 1D9I, 1DE7, 1DIT, 1DM4, 1DOJ, 1DWB, 1DWC, 1DWD, 1DX5, 1E0F, 1EB1, 1EOJ, 1EOL, 1FPC, 1G30, 1G32, 1G37, 1GHV, 1GHW, 1GHX, 1GHY, 1GJ4, 1GJ5, 1H8D, 1H8I, 1HAI, 1HAO, 1HAP, 1HBT, 1HLT, 1HUT, 1HXE, 1HXF, 1IHS, 1JMO, 1JOU, 1JWT, 1K21, 1K22, 1KTS, 1KTT, 1LHC, 1LHD, 1LHE, 1LHF, 1LHG, 1MH0, 1MU6, 1MU8, 1MUE, 1NM6, 1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 1NRS, 1NT1, 1NU7, 1NU9, 1NY2, 1NZQ, 1O0D, 1O2G, 1O5G, 1OOK, 1OYT, 1P8V, 1PPB, 1QBV, 1QHR, 1QJ1, 1QJ6, 1QJ7, 1QUR, 1RD3, 1RIW, 1SB1, 1SFQ, 1SG8, 1SGI, 1SHH, 1SL3, 1SR5, 1T4U, 1T4V, 1TA2, 1TA6, 1TB6, 1THP, 1THR, 1THS, 1TMB, 1TMU, 1TOM, 1TQ0, 1TQ7, 1TWX, 1UVS, 1VR1, 1VZQ, 1W7G, 1WAY, 1WBG, 1XM1, 1XMN, 1YPE, 1YPG, 1YPJ, 1YPK, 1YPL, 1YPM, 1Z71, 1Z8I, 1Z8J, 1ZGI, 1ZGV, 1ZRB, 2A0Q, 2A2X, 2A45, 2AFQ, 2ANK, 2ANM, 2B5T, 2BDY, 2BVR, 2BVS, 2BVX, 2BXT, 2BXU, 2C8Y, 2FEQ, 2FES, 2GDE, 2GP9, 2H9T, 2HGT, 2HNT, 2HPP, 2HPQ, 2HWL, 2JH0, 2JH6, 2OD3, 2PGB, 2PGQ, 2PW8, 2R2M, 2THF, 2ZFQ, 2ZFR, 2ZG0, 2ZHE, 2ZHF, 2ZHW, 2ZI2, 2ZIQ, 2ZNK, 2ZO3, 3B23, 3B9F, 3BEF, 3BEI, 3BF6, 3BIU, 3BIV, 3BV9, 3C1K, 3C27, 3D49, 3DA9, 3DD2, 3DT0, 3DUX, 3E6P, 3EE0, 3EQ0, 3F68, 3GIC, 3GIS, 3HAT, 3HKJ, 3HTC, 3JZ2, 3LDX, 3LU9, 3NXP, 3P17, 3P6Z, 3P70, 3PO1, 3QGN, 3QLP, 3QTO, 3QTV, 3QWC, 3QX5, 3R3G, 3RLW, 3RLY, 3RM0, 3RM2, 3RML, 3RMM, 3RMN, 3RMO, 3S7H, 3S7K, 3SHA, 3SHC, 3SI3, 3SI4, 3SQE, 3SQH, 3SV2, 3T5F, 3TU7, 3U69, 3U8O, 3U8R, 3U8T, 3U98, 3U9A, 3UTU, 3UWJ, 3VXE, 3VXF, 4BAH, 4BAK, 4BAM, 4BAN, 4BAO, 4BAQ, 4BOH, 4DIH, 4DII, 4DT7, 4DY7, 4E05, 4E06, 4E7R, 4H6S, 4H6T, 4HFP, 4HTC, 4THN, 5GDS, 7KME, 8KME, 1A46, 1A4W, 1A5G, 1A61, 1AFE, 1AHT, 1DWE, 1FPH, 1HAG, 1HAH, 1HDT, 1HGT, 1IHT, 1NO9, 1TBZ, 1TMT, 1UMA, 2C8W, 2C8X, 2C8Z, 2C90, 2C93, 2CF8, 2CF9, 2CN0, 2JH5, 2PKS, 2UUF, 2UUJ, 2UUK, 2V3H, 2V3O, 2ZC9, 2ZDA, 2ZDV, 2ZF0, 2ZFF, 2ZFP, 2ZGB, 2ZGX, 2ZHQ, 3DHK, 3EGK, 3JZ1, 3K65, 3PMH, 3QDZ, 4AX9, 4AYV, 4AYY, 4AZ2, 4CH2, 4CH8, 4HZH, 4I7Y, 4LOY, 4LXB, 4LZ1, 4LZ4, 4MLF, 4N3L, 4NZE, 4NZQ, 4O03, 4RKJ, 4RKO, 4RN6, 4YES, 4UD9, 4UDW, 4UE7, 4UEH, 5AF9, 5AFY, 5AFZ, 5AHG, 5CMX, 4UFD, 5EDM, 5E8E, 5EDK, 4UFE, 4UFG, 4UFF, 5A2M, 5JDU
Identifikatzaileak
Aliasak	F2 (HUGO), PT, RPRGL2, THPH1, coagulation factor II, thrombin
Kanpoko IDak	OMIM: 176930   MGI: 88380   HomoloGene: 426   GeneCards: F2   OMA: F2 - orthologs
Genetikoki lotutako gaixotasunak
hypoprothrombinemia , hiperkoagulazio  [1]
Drogaren xedea
dabigatran , ximelagatran , dabigatran etexilate , argatroban  [2]
Genearen kokapena (gizakia) Kromosoma: 11 (gizakia)[3] Banda 11p11.2 Hasiera 46.719.196 bp[3] Amaiera 46.739.506 bp[3]
Genearen kokapena (sagua) Kromosoma: 2 (sagua)[4] Banda 2 E1|2 50.63 cM Hasiera 91.455.665 bp[4] Amaiera 91.466.759 bp[4]
RNA adierazpen eredua Bgee gizakia sagua (ortholog) Adierazpen ohikoena right lobe of liver  Barrabil obozito secondary oocyte  cerebellar hemisphere  right hemisphere of cerebellum  popliteal artery  Tibial arteries  fundus  enbrioi Adierazpen ohikoena left lobe of liver  fetal liver hematopoietic progenitor cell  Behazun xixku Zaku bitelino umeki sexually immature organism  morula  primary oocyte  secondary oocyte  zigoto Erreferentziazko adierazpen datu gehiago BioGPS Erreferentziazko adierazpen datu gehiago
Gene ontologia Funtzio molekularra kaltzio ioi lotura  signaling receptor binding  peptidase activity  hydrolase activity  growth factor activity  serine-type peptidase activity  thrombospondin receptor activity  proteina lotura  serine-type endopeptidase activity  lipopolysaccharide binding  heparin binding  enzyme activator activity  Zelularen osagaia extracellular exosome  blood microparticle  endoplasmic reticulum lumen  Golgi lumen  zelula mintz  zelulaz kanpoko eremu  extracellular space  external side of plasma membrane  collagen-containing extracellular matrix  Prozesu biologikoa blood coagulation, intrinsic pathway  regulation of blood coagulation  positive regulation of phosphatidylinositol 3-kinase signaling  positive regulation of collagen biosynthetic process  izaki zelulanitzen garapena  peptidyl-glutamic acid carboxylation  acute-phase response  positive regulation of reactive oxygen species metabolic process  endoplasmic reticulum to Golgi vesicle-mediated transport  positive regulation of cell growth  cell surface receptor signaling pathway  gene-erregulazio  positive regulation of release of sequestered calcium ion into cytosol  positive regulation of cell population proliferation  leukocyte migration  negative regulation of fibrinolysis  positive regulation of blood coagulation  regulation of cytosolic calcium ion concentration  response to wounding  signal peptide processing  positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway  regulation of cell shape  Hemostasi  negative regulation of proteolysis  negative regulation of platelet activation  negative regulation of astrocyte differentiation  positive regulation of protein phosphorylation  Fibrinolisi  Gatzapen  proteolisi  platelet activation  positive regulation of protein localization to nucleus  positive regulation of lipid kinase activity  regulation of complement activation  antimicrobial humoral immune response mediated by antimicrobial peptide  negative regulation of cytokine production involved in inflammatory response  regulation of signaling receptor activity  G proteina errezeptore akoplatuaren komunikazio bidea  positive regulation of receptor signaling pathway via JAK-STAT  blood coagulation, fibrin clot formation  Iturburuak: : Amigo / QuickGO
Ortologoak Espeziea Gizakia Sagua Entrez 2147 14061 Ensembl ENSG00000180210 ENSMUSG00000027249 UniProt P00734 P19221 RefSeq (RNAm) NM_000506 NM_001311257 NM_010168 RefSeq (proteina) NP_000497 NP_034298 Kokapena (UCSC) Chr 11: 46.72 – 46.74 Mb Chr 2: 91.46 – 91.47 Mb PubMed bilaketa [5] [6]
Wikidata
Ikusi/Editatu giza genea Ikusi/Editatu saguaren genea

Tronbina odolaren gatzapen prozesuan parte hartzen duen funtsezko entzima da. Prozesu horretan fibrinogeno izeneko proteina disolbagarria fibrina izeneko proteina disolbaezina bihurtzen da, tronbina izanik bilakaera hori katalizatzen duen entzima.

Fibrinogeno → Fibrina

Tronbina 36 eta 259 aminoazido dituzten bi kate polipeptidikoz osaturik dago. Bi kate horiek lotura disulfurikoen bidez elkarturik daude.

Tronbina protronbina izeneko molekula batetik sortzen da. Bilakaera horretan parte hartzen duen entzima tronboplastina da, odoleko plaketek askatzen dutena odol-hodi batek kalte handia jasotzen duenean. Tronbina sortzeko prozesuan K bitaminak eta kaltzio ioiek funtsezko zeregina burutzen dute.

Tronbinari esker sortzen den fibrina odol-koaguluaren sortzailea da, odoljarioak ekiditen dituena.

1. ↑ Genetikoki lotutako gaixotasunak Tronbinaikusi/editatu erreferentziak Wikidatan. .
2. ↑ Fisikoki elkarreragiten duten drogak Tronbinaikusi/editatu erreferentziak Wikidatan. .
3. ↑ ^{a b c} GRCh38: Ensembl release 89: ENSG00000180210 - Ensembl, May 2017
4. ↑ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000027249 – Ensembl, May 2017
5. ↑ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. ↑ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.