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Smoothened

Smoothened é uma proteína do tipo receptor acoplado à proteína G[1] codificada pelo gene SMO da via de sinalização Hedgehog, conservadas de moscas a humanos. É o alvo molecular do teratógeno ciclopamina.[2]

Referências

  1. ↑ Ruiz-Gómez A, Molnar C, Holguín H, Mayor F, de Celis JF (2007). «The cell biology of Smo signalling and its relationships with GPCRs». Biochim. Biophys. Acta. 1768 (4): 901–12. PMID 17094938. doi:10.1016/j.bbamem.2006.09.020 
  2. ↑ Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA (2000). «Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine». Nature. 406 (6799): 1005–9. PMID 10984056. doi:10.1038/35023008 

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